Pore region of TRPV3 ion channel is specifically required for heat activation
نویسندگان
چکیده
منابع مشابه
Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3.
2-Aminoethyl diphenylborinate was recently identified as a chemical activator of TRPV1, TRPV2, and TRPV3, three heat-gated members of the transient receptor potential vanilloid (TRPV) ion channel subfamily. Here we demonstrated that two structurally related compounds, diphenylboronic anhydride (DPBA) and diphenyltetrahydrofuran (DPTHF), can also modulate the activity of these channels. DPBA act...
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The TRPV1 channel is a sensitive detector of pain-producing stimuli, including noxious heat, acid, inflammatory mediators, and vanilloid compounds. Although binding sites for some activators have been identified, the location of the temperature sensor remains elusive. Using available structures of TRPV1 and voltage-activated potassium channels, we engineered chimeras wherein transmembrane regio...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2008
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.2169